A mechanistic analysis placental intravascular thrombus formation in COVID-19 patients
Identifieur interne : 000796 ( Main/Exploration ); précédent : 000795; suivant : 000797A mechanistic analysis placental intravascular thrombus formation in COVID-19 patients
Auteurs : J. Justin Mulvey [États-Unis] ; Cynthia M. Magro [États-Unis] ; Lucy X. Ma [États-Unis] ; Gerard J. Nuovo [États-Unis] ; Rebecca N. Baergen [États-Unis]Source :
- Annals of Diagnostic Pathology [ 1092-9134 ] ; 2020.
Abstract
COVID-19, the disease caused by the novel Coronavirus, SARS-CoV-2, is increasingly being recognized as a systemic thrombotic and microvascular injury syndrome that may have its roots in complement activation. We had the opportunity to study the placental pathology of five full-term births to COVID-19 patients, making up the entirety of such deliveries at our hospital. All five exhibited histology indicative of fetal vascular malperfusion characterized by very focal avascular villi and thrombi in larger fetal vessels. Vascular Complement deposition in the placentas was not abnormal, and staining for viral RNA and viral spike protein was negative. While all cases resulted in healthy, term deliveries, these findings indicate the systemic nature of COVID-19 infection. The finding of vascular thrombosis without complement deposition may reflect the systemic nature of COVID-19's procoagulant effects unrelated to systemic complement activation.
Url:
DOI: 10.1016/j.anndiagpath.2020.151530
PubMed: NONE
PubMed Central: 7182529
Affiliations:
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Justin" last="Mulvey">J. Justin Mulvey</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Laboratory Medicine, Memorial Sloan-Kettering Cancer Center, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine, Memorial Sloan-Kettering Cancer Center</wicri:regionArea><wicri:noRegion>Memorial Sloan-Kettering Cancer Center</wicri:noRegion></affiliation></author><author><name sortKey="Magro, Cynthia M" sort="Magro, Cynthia M" uniqKey="Magro C" first="Cynthia M." last="Magro">Cynthia M. Magro</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine</wicri:regionArea><wicri:noRegion>Weill Cornell Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Ma, Lucy X" sort="Ma, Lucy X" uniqKey="Ma L" first="Lucy X." last="Ma">Lucy X. Ma</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine</wicri:regionArea><wicri:noRegion>Weill Cornell Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Nuovo, Gerard J" sort="Nuovo, Gerard J" uniqKey="Nuovo G" first="Gerard J." last="Nuovo">Gerard J. Nuovo</name><affiliation wicri:level="2"><nlm:aff id="af0015">The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Ohio State University Comprehensive Cancer Center, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="af0020">Discovery Life Sciences, Powell, OH, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Discovery Life Sciences, Powell, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Baergen, Rebecca N" sort="Baergen, Rebecca N" uniqKey="Baergen R" first="Rebecca N." last="Baergen">Rebecca N. Baergen</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine</wicri:regionArea><wicri:noRegion>Weill Cornell Medicine</wicri:noRegion></affiliation></author></analytic><series><title level="j">Annals of Diagnostic Pathology</title><idno type="ISSN">1092-9134</idno><idno type="eISSN">1532-8198</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>COVID-19, the disease caused by the novel Coronavirus, SARS-CoV-2, is increasingly being recognized as a systemic thrombotic and microvascular injury syndrome that may have its roots in complement activation. We had the opportunity to study the placental pathology of five full-term births to COVID-19 patients, making up the entirety of such deliveries at our hospital. All five exhibited histology indicative of fetal vascular malperfusion characterized by very focal avascular villi and thrombi in larger fetal vessels. Vascular Complement deposition in the placentas was not abnormal, and staining for viral RNA and viral spike protein was negative. While all cases resulted in healthy, term deliveries, these findings indicate the systemic nature of COVID-19 infection. The finding of vascular thrombosis without complement deposition may reflect the systemic nature of COVID-19's procoagulant effects unrelated to systemic complement activation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhu, N" uniqKey="Zhu N">N. Zhu</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D. 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Manitto</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><country name="États-Unis"><noRegion><name sortKey="Mulvey, J Justin" sort="Mulvey, J Justin" uniqKey="Mulvey J" first="J. Justin" last="Mulvey">J. Justin Mulvey</name></noRegion><name sortKey="Baergen, Rebecca N" sort="Baergen, Rebecca N" uniqKey="Baergen R" first="Rebecca N." last="Baergen">Rebecca N. Baergen</name><name sortKey="Ma, Lucy X" sort="Ma, Lucy X" uniqKey="Ma L" first="Lucy X." last="Ma">Lucy X. Ma</name><name sortKey="Magro, Cynthia M" sort="Magro, Cynthia M" uniqKey="Magro C" first="Cynthia M." last="Magro">Cynthia M. Magro</name><name sortKey="Nuovo, Gerard J" sort="Nuovo, Gerard J" uniqKey="Nuovo G" first="Gerard J." last="Nuovo">Gerard J. Nuovo</name><name sortKey="Nuovo, Gerard J" sort="Nuovo, Gerard J" uniqKey="Nuovo G" first="Gerard J." last="Nuovo">Gerard J. 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